Neptazane  (U.S.N.L.M.)
Dosing 50mg po single dose for emergency IOP reduction
(See package insert for other dosing.)
Chem Specs methazolamide
Quantities 25,  50mg tab
Cost 248.80/30tab/50mg (generic)
Class carbonic anhydrase inhibitor
Action Inhibition of carbonic anhydrase II in the ciliary processes presumably slows the
formation of bicarbonate with subsequent reduction in sodium and fluid transport.
Inhibition of carbonic anhydrase II in the ciliary processes presumably slows the formation of bicarbonate with subsequent reduction in sodium and fluid transport.
Usage Indicated in the treatment of chronic open-angle glaucoma, secondary
glaucoma, and preoperatively in acute angle-closure glaucoma
Indicated in the treatment of chronic open-angle glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma
Sulfonamides1 can cause hypersensitivity fatalities, Stevens-Johnson syndrome,
toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic
anemia and other blood dyscrasias.
Sulfonamides1 can cause hypersensitivity fatalities, Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis,aplastic anemia and other blood dyscrasias.
Contraindications Low sodium and/or potassium serum levels, marked kidney or liver disease
or dysfunction, adrenal gland failure, and hyperchloremic acidosis. In patients
with cirrhosis, use may precipitate the development of hepatic encephalopathy.
Hypersensitivity to any component of this product.
Low sodium and/or potassium serum levels, marked kidney or liver disease or dysfunction, adrenal gland failure, and hyperchloremic acidosis. In patients
with cirrhosis, use may precipitate the development of hepatic encephalopathy. Hypersensitivity to any component of this product.
Pediatric use Safety and effectiveness in children not established.
Pregnancy Category C. Teratogenic in rats when given in doses 40 times the human dose.
Anorexia, tachypnea, lethargy, coma and death have been reported with
concomitant use of high-dose aspirin and carbonic anhydrase inhibitors.
Anorexia, tachypnea, lethargy, coma and death have been reported with concomitant use of high-dose aspirin and carbonic anhydrase inhibitors.
1. Shah, Moshirfar and Hoopes argue that Neptazane may be used with caution with a known "Sulfa Allergy" provided its not a previous
"Life Threatening allergic reaction" based on the absence of the arylamine of sulfonamides and the relatively low rate of reported incidents.
https://link.springer.com/article/10.1007/s40123-018-0136-8     N.L.M. DailyMed page for Lumigan