Cortisporin  (U.S.N.L.M.)
Dosing One or two drops every 3 or 4 hours.
Chem Specs neomycin sulfate (equivalent to 3.5 mg neomycin base), polymyxin B sulfate equivalent
to 10,000 polymyxin B units, and hydrocortisone (1%)
Quantities 7.5ml
Cost 156.00
Class aminoglycoside / bactericidal peptid / steroid
Action Neomycin binds to the 30S ribosome preventing protein synthesis. Polymyxin B is a cell membrane
disruptor. Hydrocortisone (a.k.a. cortisol) inhibits phospholipase A (thus arachidonic acid metabolism).
Neomycin binds to the 30S ribosome preventing protein synthesis. Polymyxin B is a cell membrane disruptor. Hydrocortisone (a.k.a. cortisol) inhibits phospholipase A (thus arachidonic acid metabolism).
Activity Neomycin is active against Gram-negative aerobes and some anaerobic bacilli.
Polymyxin B sulfate is active against Gram-negative species.
Hydrocortisone is a weak short acting steroid.
Neomycin sulfate and polymyxin B sulfate are active against Staphylococcus aureus, Escherichia coli,
Haemophilus influenzae, Klebsiella/Enterbacter, Neisseria ,
and Pseudomonas aeruginosa.
Usage Indicated for ocular surface inflammation where risk of bacterial infection exists.
Neomycin is notable for its tendency to cause Type IV delayed hypersensitivity reaction.
May cause ocular hypertension / glaucoma, and cataract with prolonged use.
Monitor IOP if used for more than 10 days.
Contraindications Contraindicated in most viral, mycobacterial, and fungal diseases of the eye.
Pediatric use Safety and effectiveness not been established in pediatric patients.
Pregnancy Category C. Steroids topically applied to animals in the human ocular dose are teratogenic.
"Cortisporin" is the brand name used for initial approval in 1975. It was sold to Monarch
which discontinued its use in 2008. Now sold as a generic.
Preserved with thimerosal 0.001%.
"Cortisporin" is the brand name used for initial approval in 1975. It was sold to Monarch which discontinued its use in 2008. Now sold as a generic.
Preserved with thimerosal 0.001%.
    N.L.M. DailyMed page for Cortisporin         PDR page for Cortisporin