Zymar / Zymaxid  (U.S.N.L.M.)
Dosing/ conjunctivitis 1 drop q2hr on day 1, then bid to qid days 2 thru 7.
Dosing/ ulcer In office loading dose then 2drops q15min for 2-3hr, then qhr,
q3-4hr overnight (ung hs less severe cases), qhr day 2, then
q2hr to significant resolution, then qid to day 14.
In office loading dose then 2drops q15min for 2-3hr, then qhr, q3-4hr overnight (ung hs less severe cases), qhr day 2, then q2hr to significant resolution, then qid to day 14.
Chem Specs gatifloxacin 0.3 % (Zymar)      gatifloxacin 0.5%(Zymaxid)
Quantities 5ml bottle (Zymar)              2.5ml (Zymaxid)
Cost 115.05 generic
The 5ml bottle of Zymar costs only slightly more than the 2.5ml of Zymaxid.
Class fourth-generation fluoroquinolone
Action Binds bacterial DNA gyrase topoisomerase II and topoisomerase IV Binds bacterial DNA gyrase topoisomerase II and topoisomerase IV
Activity Active against a very broad range of gram negative and positive
organisms. Click heading for details in package insert.
Active against a very broad range of gram negative and positive organisms. Click heading for details in package insert.
Usage Indicated for bacterial conjunctivitis, off label for corneal ulcer.
Enhanced  gram  positive  activity  with  bulky  side  chains  which
combat resistance and enhance potency. Excellent initial kill rate.
Good Pseudomonas coverage.
Enhanced  gram  positive  activity  with  bulky  side  chains which combat resistance and enhance potency. Excellent initial kill rate. Good Pseudomonas coverage.
Contraindications Hypersensitivity to Zymar, other quinolones or any components.
Pediatric use > 1 year
Pregnancy No adequate and well-controlled studies in pregnant women.
Administration to pregnant  rats, and rabbits did not produce
adverse effects at clinically relevant doses.
No  adequate  and  well-controlled  studies  in  pregnant  women. Administration to pregnant rats, and rabbits did not produce adverse effects at clinically relevant doses.
Zymaxid is the 0.5% reformulation of Zymar.   BAK preserved.
    N.L.M. DailyMed page for Zymaxid         PDR page for Zymaxid