|click here for details           Vigamox  (U.S.N.L.M.)|
|Dosing/ conjunctivitis||1 drop tid for 7 days|
|Dosing/ corneal ulcer|| In office loading dose then 2drops q15min for 2-3hr, then qhr,
q3-4hr overnight (ung hs less severe cases), qhr day 2, then
q2hr to significant resolution, then qid to day 14.
|Chem Specs||moxifloxacin 0.5%|
|Quantities||3 ml in 4ml bottle|
|Action||Binds bacterial DNA gyrase topoisomerase II and topoisomerase IV|
|Activity|| Active against a very broad range of gram negative and positive
organisms. Click heading for details in package insert.
|Usage||Indicated for bacterial conjunctivitis, off label for corneal ulcer.|
| Enhanced gram positive activity with bulky side chains which combat
resistance and enhance potency. Superior time-kill characteristics.
Better solubility in ophthalmic solution allows higher concentration.
Biphasic molecule may explain enhanced corneal penetration.
|Contraindications||Hypersensitivity to Moxifloxacin, other quinolones or any components.|
|Pediatric use||> 1 year|
|Self preserved. Slight yellowish color.
Ophthalmic patent expiration September 29, 2019.