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Vibramycin (U.S.N.L.M.)
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| Dosing: Adult Inclusion Conjunctivitis. | 100mg bid (x 3 wks for chlamydia). Consider Zmax. | |
| Dosing: (Chronic Blepharitis) | Periostat (20mg) bid for 4 to 8 wks. (Note: generic 50mg doxycycline is much less expensive than the generic 20 mg.) |
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| Chem Specs | doxycycline | |
| Quantities | 20mg tablets, 50mg, 100mg tablets and capsules | |
| Cost | 4.00/20/100mg, 4.00/30/50mg generic | |
| Class | Broad-spectrum, long acting tetracycline. | |
| Action | Inhibits protein synthesis, binding to the 30s ribosomal subunit of the mRNA. | |
| Usage | Indicated in the treatment of inclusion conjunctivitis / trachoma and many other conditions with susceptible organisms. Anticollagenase property useful in treatment of blepharitis (meibomianitis) and recurrent corneal erosions. |
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| Photosensitivity manifested by an exaggerated sunburn reaction may occur. Dental discoloration has been reported in adults. |
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| Contraindications | Hypersensitivity to any of the tetracyclines. | |
| Pediatric use | Enamel hypoplasia and discoloration occurs in children to age 8 and in the last half of pregnancy. | |
| Pregnancy | Category D | |
| Use caution with concurrent Coumadmadin usage. Clostridium difficile associated diarrhea has been reported with nearly all antibacterial agents. Resistance is very common. |
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