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Tobrex Ointment (U.S.N.L.M.)
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| Dosing/ | bid, tid, (or q3-4 hr for severe disease) then bid or tid till end. | |
| Chem Specs | tobramycin 0.3% | |
| Quantities | 3.5 gm tube | |
| Cost | 34.00 | |
| Class | Aminoglycoside | |
| Action | Prevents bacterial protein synthesis (binds to ribosome s30 or s50) | |
| Activity | Active against a wide variety of gram-negative and gram-positive bacteria includings some penicillin-resistant and gentamicin-resistant strains . |
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| Usage | Indicated in the treatment of external infections of the eye and adnexa. | |
| Increasing resistance from community-acquired infections. Aminoglycoside toxicity possible with pre-sensitized pts. or with extended use. Polysporin is the usual alternative. |
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| Contraindications | Known hypersensitivity to any of its components. | |
| Pediatric use | > 2 months | |
| Pregnancy | Category B | |