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Tobradex ST (U.S.N.L.M.)
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| Dosing | 1 or 2 drops q4-6 hrs, q2hr 1st 24 or 48hr if needed, taper | |
| Chem Specs | tobramycin 0.3% dexamethasone 0.05% | |
| Quantities | 2.5, 5, 10ml | |
| Cost | 103.00/5ml | |
| Class | aminoglycoside corticosteroid | |
| Action | Aminoglycosides prevent bacterial protein synthesis. Corticosteroids inhibit arachidonic acid release. |
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| Activity | Active against a wide variety of gram-negative and gram-positive bacteria includings some penicillin-resistant and gentamicin-resistant strains . |
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| Usage | Indicated for steroid-responsive inflammatory conditions where superficial bacterial infection or a risk of bacterial infection exists. (Used up to one week on posterior blepharitis.) |
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| Glaucoma risk with extended use. | ||
| Contraindications | Acanthamoeba, most viral, mycobacterial, and fungal disease. Hypersensitivity to this or other aminoglycosides, corticosteroids, or any components of the medication. |
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| Pediatric use | > 2 years | |
| Pregnancy | Category C | |
| Addition of xanthan gum allows reduction of dexamethasone concentration to 0.05% without reducing efficacy. |
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