click for details →
Polytrim (U.S.N.L.M.)
| ||
|---|---|---|
| Dosing/ Conjunctivitis | 1 drop q 3hr for 7 to 10 days. | |
| Chem Specs | polymyxin B sulfate 10,000 units/mL; trimethoprim sulfate equiv 1 mg/mL. | |
| Quantities | 10ml | |
| Cost | 5.00 generic | |
| Class | Polypeptide / Sulfonamide | |
| Action | Sulfonamides competitvely inhibit bacterial folic acid synthesis. Polymyxin B increases permeability of bacterial cell membrane. |
|
| Activity | Active against a wide variety of aerobic gram-positive and gram-negative ophthalmic pathogens including Staphylococcus aureus and Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus faecalis, Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus aegyptius, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa |
|
| Usage | Indicated for surface ocular bacterial infections, including acute conjunctivitis, and blepharoconjunctivitis. |
|
| Excellent coverage of Haemophilus influenzae and Streptococcus pneumoniae makes Polytrim popular in pediatric usage. |
||
| Contraindications | Known hypersensitivity to components. | |
| Pediatric use | > 2 months | |
| Pregnancy | Category C | |
| Sometimes used as adjunctive therapy when fluoroquinolone resistance is suspected. |
||