Polytrim  (U.S.N.L.M.)
Dosing/ Conjunctivitis 1 drop q 3hr for 7 to 10 days.
Chem Specs polymyxin B sulfate 10,000 units/mL; trimethoprim sulfate equiv 1 mg/mL.
Quantities 10ml
Cost 22.57 generic
Class Polypeptide / Sulfonamide
Action Trimethoprim - prevents bacterial folic acid synthesis (inhibits bacterial DNA synthesis).
Polymyxin B - surfactant acts on phospholipids of bacterial cell membrane.
Activity Active against a wide variety of aerobic gram-positive and gram-negative
ophthalmic pathogens including Staph aureus and Pseudomonas aeruginosa.
Fewer than 10% of S. aureus and methicillin-resistant S. aureus resistant to trimethoprim (2018).
Active against a wide variety of aerobic gram-positive and gram-negative ophthalmic pathogens including Staph aureus and Pseudomonas aeruginosa. Fewer than 10% of S. aureus and methicillin-resistant S. aureus resistant to trimethoprim (2018).
Usage Indicated for surface ocular bacterial infections, including acute
conjunctivitis, and blepharoconjunctivitis.
Indicated for surface ocular bacterial infections, including acute conjunctivitis, and blepharoconjunctivitis.
Excellent coverage of Haemophilus influenzae and Streptococcus pneumoniae
makes Polytrim popular in pediatric usage.
Excellent coverage of Haemophilus influenzae and Streptococcus pneumoniae makes Polytrim popular in pediatric usage.
Contraindications Known hypersensitivity to components.
Pediatric use > 2 months
Pregnancy No large well-controlled studies on the use of trimethoprim in pregnant women.
Small retrospective studies have not shown teratogenicity.
Useful as adjunctive therapy when fluoroquinolone resistance is suspected.
    N.L.M. DailyMed page for Polytrim         PDR page for Polytrim