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Moxeza (U.S.N.L.M.)
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| Dosing/ conjunctivitis | 1 drop bid for 7 days | |
| Dosing/ corneal ulcer | In office loading dose then 2drops q15min for 2-3hr, then qhr, q3-4hr overnight (ung hs less severe cases), qhr day 2, then q2hr to significant resolution, then qid to day 14. |
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| Chem Specs | moxifloxacin 0.5% | |
| Quantities | 3 ml in 4ml bottle | |
| Cost | 74.00 | |
| Class | fourth-generation fluoroquinolone | |
| Action | Binds bacterial DNA gyrase topoisomerase II and topoisomerase IV | |
| Activity | Active against a very broad range of gram negative and positive organisms. Click heading for details in package insert. |
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| Usage | Indicated for bacterial conjunctivitis, off label for corneal ulcer. | |
| Enhanced gram positive activity with bulky side chains which combat resistance and enhance potency. Superior time-kill characteristics. Better solubility in ophthalmic solution allows higher concentration. Biphasic molecule may explain enhanced corneal penetration. |
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| Contraindications | Hypersensitivity to Moxifloxacin, other quinolones or any components. | |
| Pediatric use | Safety and effectivenessin infants below 4 months of age have not been established. | |
| Pregnancy | Category C | |
| Self preserved. Xanthan gum increases time of residence on the eye. |
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