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Combigan (U.S.N.L.M.)
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|---|---|---|
| Dosing | 1 drop bid, 12 hours apart | |
| Chem Specs | brimonidine tartrate 0.2% / timolol maleate 0.5% | |
| Quantities | 5 ml in 10 ml bottle, 10 ml in 10 ml bottle | |
| Cost | 68.00/5ml | |
| Class | Relatively selective alpha-2 adrenergic receptor agonist / beta blocker | |
| Action | Brimonidine reduces aqueous production and increases uveoscleral outflow. Timolol reduces aqueous formation by blocking beta2 receptors on nonpigmented ciliary epithelium |
|
| Usage | Indicated as adjunctive or replacement therapy for the reduction of IOP in patients with glaucoma or ocular hypertension with inadequately controlled IOP. |
|
| About 5% incidence or allergic conjunctivitis. 14% discontinuation from all adverse effects. | ||
| Contraindications | Bronchial asthma, sinus bradycardia, COPD, overt cardiac failure, cardiogenic shock, atrioventricular block and hypersensitivity to any of the product contents. |
|
| Pediatric use | > age 2 | |
| Pregnancy | Category C | |
| 22% IOP reduction on average. BAK preserved. | ||