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Ciloxan (U.S.N.L.M.)
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| Dosing/Corneal Ulcer | 2 drops q15min x 6hr, then q30min remainder of day 1, then qhr day 2, then q4hr to day 14. Consider ung qhs. |
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| Dosing/ Conjunctivitis | 1 or 2 drops q2hr x 2 days, then q4hr next 5 days. | |
| Chem Specs | ciprofloxacin HCL 0.3% | |
| Quantities | 2.5, 5, 10ml | |
| Cost | 36.00 | |
| Class | fluoroquinolone, second generation | |
| Action | Binds bacterial DNA gyrase preventing protein synthesis | |
| Activity | Active against a broad spectrum of gram positive and negative organisms. | |
| Usage | Indicated for the treatment of corneal ulcers and conjunctivitis. (See package insert for susceptible organisms.) | |
| Second-generation fluoroquinolone antibiotics were good topical agents due to wide spectrum of antimicrobial activity, low toxicity, high potency, prolonged tear film concentration, and stability in solution. |
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| Contraindications | Quinolone hypersensitivity | |
| Pediatric use | Over age 1 | |
| Pregnancy | C | |
| Increasing gram-positive resistance found in bacterial keratitis. Up to 85% resistance for coagulase-negative Staphyloccus. |
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