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Blephamide (U.S.N.L.M.)
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| Dosing | 2 drops q4hr, evaluate after 2 days, taper | |
| Chem Specs | sulfacetamide 10%, prednisolone acetate (suspension) 0.2%. | |
| Quantities | 5, 10ml | |
| Cost | 20.00/5ml generic | |
| Class | sulfonamide/corticosteroid | |
| Action | Sulfonamides inhibit bacterial folate synthesis. Corticosteroids inhibit the release of arachidonic acid. |
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| Activity | Sulfacetamide is active against certain strains of Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus (viridans group), Haemophilus influenzae, Klebsiella species, and Enterobact. |
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| Usage | Indicated for ocular surface inflammation where superficial bacterial infection or a risk of bacterial infection exists. |
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| Inadequate coverage against: Neisseria species, Pseudomonas species, and Serratia marcescens. Many Staphylococcal isolates are completely resistant to sulfa drugs. Hypersensitivity to sulfonamides is common. Glaucoma risk. |
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| Contraindications | Acanthamoeba, viral, mycobacterial, and fungal disease. Hypersensitivity to this or other sulfonamides or corticosteroids. |
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| Pediatric use | > 6 years | |
| Pregnancy | Category C. | |