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Augmentin (U.S.N.L.M.)
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| Dosing: (Dacryocystitis, Preseptal Cellulitis) | Mild to Moderate: 250mg tid to 500mg bid(q12hr). Severe: 500mg tid to 875mg bid(q12hr). | |
| Chem Specs | amoxicillin / clavulanate | |
| Quantities | Tablets(250, 500, 875mg), Chewable(125, 200, 250, 400mg), Suspension(125, 200, 250, 400mg). | |
| Cost | 64.00/30/500mg generic | |
| Class | moderate-spectrum ß-lactam antibiotic / ß-lactamase inhibitor | |
| Action | Inhibits cross-linkage between the peptidoglycan polymer chains of bacterial cell wall. / Inhibits bacterial ß-lactamase enzyme. |
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| Usage | Augmentin is used to treat infections caused by the ß-lactamase producing strains of H. influenzae, M. catarrhalis, S. aureus, E. coli, Klebsiella spp as well as ampicillin-susceptible organisms particularly S. pneumoniae. |
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| The q12hr regimen is preferred. 10 day course is typical. | ||
| Contraindications | Allergy to any of the penicillins. Previous cholestatic jaundice/hepatic dysfunction associated with Augmentin. |
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| Pediatric use | Consult dosing tables (package insert) and warnings for children under 40kg. | |
| Pregnancy | Category B | |