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Atropine (U.S.N.L.M.)
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| Dosing (uveitis/iritis) | 1 or 2 drops up to 4 times daily (1% bid typically) | |
| Dosing (cycloplegia) | 1 or 2 drops 0.5% bid for 1 to 3 days before examination | |
| Chem Specs | atropine sulfate 0.5%, 1%, 2% | |
| Quantities | 2,5,15ml | |
| Cost | 4.00 generic | |
| Class | anticholinergic | |
| Action | Competitive antagonist for the muscarinic acetylcholine receptor. | |
| Usage | Indicated for cycloplegic refraction or for pupil dilation in acute inflammatory conditions of the iris and uveal tract. |
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| Increased susceptibility in infants, young children, and in children with blond hair, blue eyes, Down's syndrome, spastic paralysis, or brain damage. The ointment dosage form is generally preferred for use in children, as the solution presents a greater chance of systemic absorption. |
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| Contraindications | Primary glaucoma or a predisposition toward narrow angle glaucoma. Iris lens synechiae. Pediatric patients who have previously had a severe systemic reaction to atropine. The elderly and others where undiagnosed glaucoma or excessive pressure in the eye may be present. Hypersensitivity to atropine or product contents. |
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| Pediatric use | > 3 months | |
| Pregnancy | Category C | |
| Peak mydriasis 30-40 min. Peak cycloplegia 1-2 hrs. Recovery 6-12 days. Nasolacrimal pressure recommended. |
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